There is no cure for lead poisoning. The primary and most crucial step in the clinical management of a lead-exposed child is to identify and eliminate the exposure. Public Health Departments can be valuable partners in identifying and mitigating or eliminating the source of exposure. However, clinicians should be aware of the most common exposure sources and be able to provide guidance to families on identifying and reducing potential exposures. The most common source of lead exposure in the United States is lead-based paint from structures built before 1978. Other sources can be more challenging to identify. They may include (but are not limited to) soil, imported cookware, water, nutritional supplements, folk or traditional medicines, imported food (including spices), cosmetics, toys and children’s jewelry, ceramic dishware, and cultural/religious powders. Household members may bring lead into the home from hobby or workplace exposures. Additional testing and clinical interventions are dependent on the BLL. In cases where the child is symptomatic and/or the BLL ≥ 45 μg/dL, chelation therapy may be necessary. Acutely symptomatic children should be treated as medical emergencies.